Metabolic engineering for the microbial production of 1,3-propanediol

Curr Opin Biotechnol. 2003 Oct;14(5):454-9. doi: 10.1016/j.copbio.2003.08.005.


Improvements in the biological production of 1,3-propanediol, a key component of an emerging polymer business, have been realized. Utilizing genes from natural strains that produce 1,3-propanediol from glycerol, metabolic engineering has enabled the development of a recombinant strain that utilizes the lower cost feedstock D-glucose. This accomplishment bodes well for future metabolic engineering efforts and, ultimately, for increased societal benefit obtained through the production of chemicals from renewable resources.

Publication types

  • Review

MeSH terms

  • Bacteria / genetics
  • Bacteria / metabolism*
  • Biological Transport
  • Catalysis
  • Cobamides / metabolism
  • Fermentation
  • Glucose / metabolism
  • Industrial Microbiology
  • Propylene Glycols / chemical synthesis
  • Propylene Glycols / metabolism*
  • Protein Engineering / methods*


  • Cobamides
  • Propylene Glycols
  • 1,3-propanediol
  • cobamamide
  • Glucose