Combined effects of mild hypothermia and glycoprotein IIb/IIIa antagonists on platelet-platelet and leukocyte-platelet aggregation

Am J Cardiol. 2003 Nov 1;92(9):1099-101. doi: 10.1016/j.amjcard.2003.06.007.

Abstract

Endovascular cooling was assessed as a potential treatment for percutaneous coronary intervention in patients with acute myocardial infarction. Here we show that mild hypothermia: (1) inhibits platelet aggregation; (2) augments eptifibatide- and tirofiban- but not abciximab-induced inhibition of platelet aggregation; (3) increases the formation of adenosine diphosphate-induced leukocyte-platelet aggregates; and (4) diminishes the glycoprotein IIb/IIIa antagonist-induced decrease in leukocyte-platelet aggregates.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abciximab
  • Adult
  • Antibodies, Monoclonal / pharmacology
  • Eptifibatide
  • Female
  • Humans
  • Hypothermia, Induced*
  • Immunoglobulin Fab Fragments / pharmacology
  • In Vitro Techniques
  • Leukocytes / drug effects*
  • Male
  • Middle Aged
  • Peptides / pharmacology
  • Platelet Adhesiveness / drug effects*
  • Platelet Aggregation / drug effects*
  • Platelet Glycoprotein GPIIb-IIIa Complex / antagonists & inhibitors*
  • Platelet Glycoprotein GPIIb-IIIa Complex / pharmacology*
  • Tirofiban
  • Tyrosine / analogs & derivatives*
  • Tyrosine / pharmacology

Substances

  • Antibodies, Monoclonal
  • Immunoglobulin Fab Fragments
  • Peptides
  • Platelet Glycoprotein GPIIb-IIIa Complex
  • Tyrosine
  • Tirofiban
  • Eptifibatide
  • Abciximab