Bone marrow plays a role in bone metabolism: histomorphometry of iliac bone in postmenopausal women

Calcif Tissue Int. 1992 Nov;51(5):348-51. doi: 10.1007/BF00316878.


We conducted a histomorphometrical study on the role of the bone marrow in cancellous bone metabolism using iliac bone specimens from 79 postmenopausal women. A gradual decrease in hematopoietic tissue of the bone marrow was proportionate to the decrease in cancellous bone and the ratio of osteoid perimeter/bone perimeter regardless of age. On the other hand, the ratio of eroded perimeter/bone perimeter remained almost steady until hematopoietic tissue decreased significantly. These findings suggest that a change in the bone marrow, that is, a decrease in hematopoietic tissue, causes an imbalance in bone formation and resorption and leads to bone loss.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Bone Marrow / anatomy & histology
  • Bone Marrow / physiology*
  • Bone Resorption / physiopathology*
  • Bone and Bones / metabolism*
  • Female
  • Humans
  • Ilium
  • Middle Aged
  • Osteoblasts / cytology
  • Osteoporosis, Postmenopausal / physiopathology*