Serum Levels of Insulin-Like Growth factor-I, IGF-binding Protein 1 and 3, and Insulin and Endometrial Cancer Risk

Br J Cancer. 2003 Nov 3;89(9):1697-704. doi: 10.1038/sj.bjc.6601312.

Abstract

Insulin-like growth factor-I (IGF-I) and IGF-binding protein-1 and 3 (IGFPB-1, IGFPB-3) are expressed in normal and neoplastic endometrium. Their role and the role of insulin in the aetiology of endometrial cancer, is unclear. We performed a population-based case-control study in Sweden, including 288 endometrial cancer patients and 392 control women and analysed total serum IGF-I, IGFBP-1, IGFBP-3, insulin and BMI levels stratified by disease and hormone replacement therapy status (HRT). Non-parametric statistical tests and logistic regression analyses were performed to assess associations with endometrial cancer. There were no substantial differences between the mean serum levels of IGF-I between cases (115.5, s.d. 61.3) and controls (110.6; s.d. 50.4; Wilcoxon P=0.84), or between subgroups of women classified according to other risk factors for endometrial cancer. There were no trends of increasing risk according to quartiles of IGF-I, IGFBP-1, IGFBP-3 and insulin serum levels. There was an increasing risk of endometrial cancer according to the serum levels of IGFBP-1, which was observed only among women who had ever used HRT. Serum IGF-I, IGFBP-1, IGFBP-3 and insulin levels seem unrelated to endometrial cancer risk. Among users of HRT, increasing IGFBP-1 levels seem to increase endometrial cancer risk.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Factors
  • Aged
  • Body Mass Index
  • Case-Control Studies
  • Contraceptives, Oral / adverse effects
  • Endometrial Neoplasms / blood*
  • Endometrial Neoplasms / etiology
  • Female
  • Hormone Replacement Therapy / adverse effects
  • Humans
  • Insulin / blood*
  • Insulin-Like Growth Factor Binding Protein 1 / blood*
  • Insulin-Like Growth Factor Binding Protein 3 / blood*
  • Intercellular Signaling Peptides and Proteins / blood*
  • Middle Aged
  • Risk Factors
  • Sweden

Substances

  • Contraceptives, Oral
  • Insulin
  • Insulin-Like Growth Factor Binding Protein 1
  • Insulin-Like Growth Factor Binding Protein 3
  • Intercellular Signaling Peptides and Proteins
  • myotrophin