Death receptors

Essays Biochem. 2003;39:53-71. doi: 10.1042/bse0390053.

Abstract

Death receptors [Fas/Apo-1/CD95, TNF-R1 [tumour necrosis factor (TNF) receptor 1], DR3 [death receptor 3], TRAIL-R1 [TNF-related apoptosis-inducing ligand receptor 1], TRAIL-R2, DR6, p75-NGFR [p75-nerve growth factor receptor], EDAR [ectodermal dysplasia receptor]] form a subgroup of the TNF-R superfamily that can induce apoptosis (programmed cell death) via a conserved cytoplasmic signalling module termed the death domain. Although death receptors have been recognized mainly as apoptosis inducers, there is growing evidence that these receptors also fulfil a variety of nonapoptotic functions. This review is focused on the molecular mechanisms of apoptotic and non-apoptotic death receptor signalling in light of the phenotype of mice deficient in the various death receptors.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Apoptosis*
  • Edar Receptor
  • Membrane Proteins / metabolism
  • Mice
  • Models, Biological
  • Receptor, Nerve Growth Factor / metabolism
  • Receptors, Ectodysplasin
  • Receptors, TNF-Related Apoptosis-Inducing Ligand
  • Receptors, Tumor Necrosis Factor / metabolism
  • Receptors, Tumor Necrosis Factor, Member 25
  • Signal Transduction
  • fas Receptor / metabolism

Substances

  • EDAR protein, human
  • Edar Receptor
  • Edar protein, mouse
  • Membrane Proteins
  • Receptor, Nerve Growth Factor
  • Receptors, Ectodysplasin
  • Receptors, TNF-Related Apoptosis-Inducing Ligand
  • Receptors, Tumor Necrosis Factor
  • Receptors, Tumor Necrosis Factor, Member 25
  • TNFRSF10A protein, human
  • TNFRSF10B protein, human
  • TNFRSF25 protein, human
  • Tnfrsf10b protein, mouse
  • Tnfrsf21 protein, mouse
  • Tnfrsf25 protein, mouse
  • fas Receptor