Germ plasm: protein degradation in the soma

Curr Biol. 2003 Oct 28;13(21):R837-9. doi: 10.1016/j.cub.2003.10.016.


Germ plasm is a specialized cytoplasm that is physically segregated to the germline cells during early embryogenesis. Recent results suggest that, in Caenorhabditis elegans, germ plasm is also prevented from accumulating in somatic lineages by a ubiquitin ligase that targets germ plasm proteins for degradation.

Publication types

  • Review

MeSH terms

  • Animals
  • Caenorhabditis elegans / embryology*
  • Cell Lineage / physiology
  • Cytoplasm / metabolism
  • Cytoplasm / physiology*
  • Cytoplasmic Granules / metabolism
  • Germ Cells / cytology*
  • Germ Cells / physiology
  • Ubiquitin-Protein Ligase Complexes / metabolism*
  • Ubiquitin-Protein Ligases / metabolism


  • Ubiquitin-Protein Ligase Complexes
  • Ubiquitin-Protein Ligases