Abstract
3-Alkoxy-5-isoxazolidinones mimic the action of beta-lactams. They bind to the penicillin-binding proteins. They inhibit Class A, Class B, and Class D beta-lactams. They inhibit the growth of Bacillus subtilis. We give a novel synthesis for these compounds.
Publication types
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Comparative Study
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Evaluation Study
MeSH terms
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology
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Bacillus subtilis / cytology
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Bacillus subtilis / drug effects*
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Bacillus subtilis / growth & development*
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Bacterial Proteins / chemistry*
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Biomimetic Materials / chemical synthesis
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Biomimetic Materials / chemistry*
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Biomimetic Materials / pharmacology*
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Biomimetics / methods
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Carrier Proteins / chemistry*
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Cell Division / drug effects
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Hexosyltransferases / chemistry*
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Isoxazoles / chemical synthesis
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Isoxazoles / chemistry*
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Isoxazoles / pharmacology*
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Microbial Sensitivity Tests
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Molecular Sequence Data
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Muramoylpentapeptide Carboxypeptidase / chemistry*
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Penicillin-Binding Proteins
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Peptidyl Transferases / chemistry*
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Protein Binding
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beta-Lactamase Inhibitors*
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beta-Lactams / chemistry*
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beta-Lactams / pharmacology
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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Carrier Proteins
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Isoxazoles
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Penicillin-Binding Proteins
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beta-Lactamase Inhibitors
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beta-Lactams
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Peptidyl Transferases
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Hexosyltransferases
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Muramoylpentapeptide Carboxypeptidase
Associated data
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SWISSPROT/PBP1
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SWISSPROT/PBP1A
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SWISSPROT/PBP2B
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SWISSPROT/PBP4
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SWISSPROT/PBP4A
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SWISSPROT/PBP5
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SWISSPROT/SP5D