3-alkoxy-5-isoxazolidinones mimic beta-lactams

Biochem Biophys Res Commun. 2003 Nov 14;311(2):267-71. doi: 10.1016/j.bbrc.2003.09.210.

Abstract

3-Alkoxy-5-isoxazolidinones mimic the action of beta-lactams. They bind to the penicillin-binding proteins. They inhibit Class A, Class B, and Class D beta-lactams. They inhibit the growth of Bacillus subtilis. We give a novel synthesis for these compounds.

Publication types

  • Comparative Study
  • Evaluation Study

MeSH terms

  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology
  • Bacillus subtilis / cytology
  • Bacillus subtilis / drug effects*
  • Bacillus subtilis / growth & development*
  • Bacterial Proteins / chemistry*
  • Biomimetic Materials / chemical synthesis
  • Biomimetic Materials / chemistry*
  • Biomimetic Materials / pharmacology*
  • Biomimetics / methods
  • Carrier Proteins / chemistry*
  • Cell Division / drug effects
  • Hexosyltransferases / chemistry*
  • Isoxazoles / chemical synthesis
  • Isoxazoles / chemistry*
  • Isoxazoles / pharmacology*
  • Microbial Sensitivity Tests
  • Molecular Sequence Data
  • Muramoylpentapeptide Carboxypeptidase / chemistry*
  • Penicillin-Binding Proteins
  • Peptidyl Transferases / chemistry*
  • Protein Binding
  • beta-Lactamase Inhibitors*
  • beta-Lactams / chemistry*
  • beta-Lactams / pharmacology

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Carrier Proteins
  • Isoxazoles
  • Penicillin-Binding Proteins
  • beta-Lactamase Inhibitors
  • beta-Lactams
  • Peptidyl Transferases
  • Hexosyltransferases
  • Muramoylpentapeptide Carboxypeptidase

Associated data

  • SWISSPROT/PBP1
  • SWISSPROT/PBP1A
  • SWISSPROT/PBP2B
  • SWISSPROT/PBP4
  • SWISSPROT/PBP4A
  • SWISSPROT/PBP5
  • SWISSPROT/SP5D