Aspirin and the fibrinolytic response

Thromb Res. 2003 Jun 15;110(5-6):331-4. doi: 10.1016/j.thromres.2003.08.006.


Apart from the anti-inflammatory action, aspirin (ASA) by inhibiting thromboxane A2 synthesis, decreases platelets activity and possesses the antithrombotic action. However, an ASA effect on fibrinolysis has not been yet finally established. Menon [Lancet 1 (1970) 364] reported increased fibrinolytic response in patients treated with high doses of ASA and this observation started a series of studies to find the relation between aspirin and fibrinolysis. This review comprises the results of those studies, divided into in vitro and in vivo, animal and human experiments. The results of our animal studies are also included. Data survey shows that the ASA effect on fibrinolysis depends on experimental conditions, the dose and the time of drug administration. The results of our study indicate the essential role of plasma components in the fibrinolysis regulation by ASA.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Aspirin / administration & dosage*
  • Dose-Response Relationship, Drug
  • Endothelial Cells / drug effects*
  • Endothelial Cells / physiology*
  • Fibrinolysis / drug effects*
  • Fibrinolysis / physiology*
  • Fibrinolytic Agents / pharmacology
  • Humans
  • Platelet Activation / drug effects*
  • Platelet Activation / physiology*


  • Fibrinolytic Agents
  • Aspirin