Upregulation of vascular extracellular superoxide dismutase in patients with acute coronary syndromes

Arterioscler Thromb Vasc Biol. 2004 Jan;24(1):106-11. doi: 10.1161/01.ATV.0000104240.56460.AB. Epub 2003 Oct 30.


Objective: We examined the vascular expression levels of extracellular superoxide dismutase (EC-SOD), a major antioxidant enzyme in the cardiovascular system, in patients with acute coronary syndromes.

Methods and results: Twenty-one consecutive patients with acute myocardial infarction (AMI), 14 patients with unstable angina, 11 patients with stable angina, and 20 control subjects were studied. The levels of vascular EC-SOD expression were assessed by the difference in plasma EC-SOD concentrations before and after intravenous heparan injection. In the patients with AMI, vascular EC-SOD expression (ng/mL) was significantly higher on day 1 after the onset of AMI (148+/-10) as compared with the control subjects (116+/-6, P<0.05). The vascular EC-SOD expression returned to the normal range on day 7 (104+/-8), and that level persisted thereafter. The vascular EC-SOD expression was also significantly higher in the patients with unstable angina (160+/-13) than in those with stable angina (122+/-10) or in the controls (116+/-6) (P<0.05 each). Moreover, in the patients with AMI, higher levels of vascular EC-SOD expression on day 1 were significantly associated with smaller myocardial infarct size (P<0.05).

Conclusions: This is the first clinical demonstration showing that vascular EC-SOD may be upregulated in acute coronary syndromes in humans in vivo. EC-SOD may play an important protective role against increased oxidative stress during acute ischemic coronary events.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Disease
  • Adult
  • Aged
  • Aged, 80 and over
  • Aging / metabolism
  • Coronary Disease / drug therapy
  • Coronary Disease / enzymology*
  • Coronary Disease / therapy
  • Enzyme Induction
  • Female
  • Heparitin Sulfate / pharmacology
  • Heparitin Sulfate / therapeutic use
  • Humans
  • Hypercholesterolemia / enzymology
  • Male
  • Middle Aged
  • Muscle, Smooth, Vascular / enzymology*
  • Myocardial Infarction / enzymology
  • Myocardial Infarction / pathology
  • Oxidative Stress
  • Oxygen Inhalation Therapy
  • Prospective Studies
  • Superoxide Dismutase / biosynthesis*
  • Superoxide Dismutase / blood
  • Superoxide Dismutase / genetics


  • Heparitin Sulfate
  • SOD3 protein, human
  • Superoxide Dismutase