[The laminopathy saga]

Rev Neurol. 2003 Oct;37(8):772-4.
[Article in Spanish]

Abstract

Aims: Our aim was to clinically characterise Emery-Dreifuss muscular dystrophy, to differentiate the X-linked forms of inheritance from the forms involving autosomal dominant inheritance, from a genetic point of view, and to describe the phenotypical heterogeneity of mutations in the LMNA gene itself.

Development: We describe the identification of the mutations in the lamina A/C gene, the LMNA gene, which was made possible thanks to the networks allowing workers in different countries to collaborate. Mutations in this gene are responsible for autosomal dominant Emery-Dreifuss disease, as well as other diseases that are phenotypically very distinct, such as limb girdle muscular dystrophy associated with cardiac conduction defects (LGMD1B), dilated myocardiopathy with conduction defects (DCM-CD), Dunnigan-type familial partial lipodystrophy (FPLD) and, finally, an autosomal recessive form of axonal neuropathy or Charcot-Marie-Tooth disease type 2 (AR-CMT).

Conclusions: Laminas are intermediate filaments that constitute the inner nuclear membrane of any cell and the mutations in the lamina A/C gene can give rise to such distinct clinical patterns as a kind of muscular dystrophy that is similar to the well known X-linked Emery-Dreifuss disease or a form of Charcot-Marie-Tooth-type neuropathy. Work is currently being conducted on an experimental animal model capable of providing us with a better understanding of the physiopathological mechanisms involved in the production of these tissue-specific diseases, although they are due to mutations in a gene that codifies for proteins that are expressed all over.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Animals
  • Chromosome Disorders / genetics
  • Chromosome Disorders / physiopathology
  • Humans
  • Lamin Type A / genetics*
  • Lamin Type A / metabolism
  • Muscular Dystrophy, Emery-Dreifuss / genetics*
  • Muscular Dystrophy, Emery-Dreifuss / pathology
  • Muscular Dystrophy, Emery-Dreifuss / physiopathology
  • Mutation
  • Phenotype

Substances

  • Lamin Type A
  • lamin C