Pentobarbital sodium coma for refractory intracranial hypertension

J Neurosci Nurs. 2003 Oct;35(5):252-62. doi: 10.1097/01376517-200310000-00003.

Abstract

Refractory intracranial hypertension (RICH) is defined as intracranial pressures that exceed 25 mm Hg for 30 minutes, 30 mm Hg for 15 minutes, or 40 mm Hg for 1 minute. RICH occurs in approximately 15% of patients with traumatic brain injury. If it is not aggressively treated, RICH can result in cerebral herniation and death. Pentobarbital sodium coma is a second-tier treatment that can be used to treat RICH. Understanding the principal mechanics of this therapy is key to the successful management of RICH and quality patient care.

Publication types

  • Review

MeSH terms

  • Critical Care / methods
  • Disease Progression
  • Drug Monitoring / methods
  • Drug Monitoring / nursing
  • Electroencephalography
  • Humans
  • Hypnotics and Sedatives / pharmacology
  • Hypnotics and Sedatives / therapeutic use*
  • Intracranial Hypertension / complications
  • Intracranial Hypertension / drug therapy*
  • Intracranial Hypertension / nursing*
  • Intracranial Hypertension / physiopathology
  • Intracranial Pressure
  • Nurse's Role
  • Nursing Assessment
  • Pentobarbital / pharmacology
  • Pentobarbital / therapeutic use*
  • Practice Guidelines as Topic

Substances

  • Hypnotics and Sedatives
  • Pentobarbital