In vivo multi-tissue corticosteroid microarray time series available online at Public Expression Profile Resource (PEPR)

Pharmacogenomics. 2003 Nov;4(6):791-9. doi: 10.1517/phgs.4.6.791.22816.

Abstract

Gene microarrays are becoming a key tool for the analysis of changes in gene expression in a variety of conditions. Use of microarrays to analyze drug responses has mainly been restricted to comparing treated versus untreated samples at a few time points. Such data do not permit the use of another important tool, pharmacokinetic/pharmacodynamic (PK/PD) modeling. Such modeling requires the simultaneous analysis of pharmacokinetic data along with time series data on dynamic responses. This report describes data obtained from two extended microarray time series (rat liver and skeletal muscle) for the in vivo responses to a single bolus dose of methylprednisolone that are uniquely available online in a single gene query format. Use of these data does not require any a priori knowledge or software normally necessary for the analysis of microarray data. Since the pharmacokinetic data and receptor model have been published, the results are amenable to PK/PD and pharmacogenomic evaluation.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adrenal Cortex Hormones / genetics*
  • Adrenal Cortex Hormones / pharmacokinetics
  • Adrenal Cortex Hormones / therapeutic use
  • Animals
  • Humans
  • Internet* / trends
  • Liver / drug effects
  • Liver / metabolism*
  • Muscle, Skeletal / drug effects
  • Muscle, Skeletal / metabolism*
  • Oligonucleotide Array Sequence Analysis / methods*
  • Oligonucleotide Array Sequence Analysis / trends
  • Organ Specificity / genetics
  • Rats
  • Time Factors

Substances

  • Adrenal Cortex Hormones