EGF receptor expression in primary laryngeal cancer: correlation with clinico-pathological features and prognostic significance

Int J Cancer. 1992 Dec 2;52(6):862-6. doi: 10.1002/ijc.2910520605.


Epidermal-growth-factor-receptor(EGFR) expression was evaluated in 103 primary laryngeal tumors and in 42 normal laryngeal tissue specimens. Significantly higher EGFR levels were found in cancer specimens than in normal mucosa (p = 0.0053). EGFR expression did not correlate with age, tumor localization, T classification, cervical-lymph-node involvement or type of surgery, whereas it was higher in poorly differentiated tumors (G3) than in well/moderately differentiated (G1-G2) tumors (p < 0.05). Follow-up data were available for 74 patients. When EGFR status and the most important clinico-pathological characteristics were submitted to univariate analysis, tumor localization, type of surgery and EGFR status were found to be significantly correlated with disease-free survival. The 24-month disease-free survival rate was 58% for EGFR+ cancer patients and 82% for EGFR- ones. With multivariate analysis, only EGFR status and tumor localization were identified as significant independent prognostic parameters. Data reported here suggest that high EGFR levels may identify a sub-set of laryngeal-cancer patients with a particularly unfavorable prognosis.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Analysis of Variance
  • ErbB Receptors / analysis*
  • Female
  • Humans
  • Iodine Radioisotopes
  • Laryngeal Neoplasms / chemistry*
  • Laryngeal Neoplasms / pathology*
  • Male
  • Middle Aged
  • Prognosis
  • Prospective Studies
  • Radioligand Assay
  • Recurrence
  • Survival Analysis


  • Iodine Radioisotopes
  • ErbB Receptors