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Review
, 130 (24), 5869-84

Mechanisms of Germ Cell Specification Across the Metazoans: Epigenesis and Preformation

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Review

Mechanisms of Germ Cell Specification Across the Metazoans: Epigenesis and Preformation

Cassandra G Extavour et al. Development.

Abstract

Germ cells play a unique role in gamete production, heredity and evolution. Therefore, to understand the mechanisms that specify germ cells is a central challenge in developmental and evolutionary biology. Data from model organisms show that germ cells can be specified either by maternally inherited determinants (preformation) or by inductive signals (epigenesis). Here we review existing data on 28 metazoan phyla, which indicate that although preformation is seen in most model organisms, it is actually the less prevalent mode of germ cell specification, and that epigenetic germ cell specification may be ancestral to the Metazoa.

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