Correlation of corpus callosal morphometry with cognitive and motor function in periventricular leukomalacia

Neuropediatrics. 2003 Jun;34(5):247-52. doi: 10.1055/s-2003-43259.


Purpose: We aim to correlate size and shape of corpus callosum with severity of motor and cognitive impairments in children with periventricular leukomalacia (PVL).

Methods: Children with PVL were stratified based on the severity of their motor and cognitive impairments. An age-matched control group was established. The corpus callosum was identified on mid-sagittal T (1)-weighted spin-echo (TR/TE: 550/15) MR images. The shape characteristics of the corpus callosum were measured with respect to a template via a shape transformation. The degree of callosal-shape transformation was quantified by a deformation function, which in turn was compared, using point-wise T-tests, for controls versus patients, diplegic versus quadriplegic patients, and patients with mild versus severe cognitive impairment.

Results: 29 children with spastic cerebral palsy and PVL and 32 age-matched controls were identified. In the PVL group, the entire corpus callosum was significantly smaller than in the control group (p value = 0.001). Significant differences existed in the shape of the corpus callosum between patients with diplegic versus quadriplegic and between patients with severe versus mild cognitive impairment.

Conclusion: Global and regional corpus callosal morphology can be quantified using deformation functions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Agenesis of Corpus Callosum*
  • Cerebral Palsy / complications*
  • Cerebral Palsy / diagnosis
  • Child
  • Child, Preschool
  • Cognition Disorders / diagnosis
  • Cognition Disorders / etiology*
  • Corpus Callosum / physiopathology*
  • Humans
  • Infant
  • Infant, Newborn
  • Leukomalacia, Periventricular / complications*
  • Magnetic Resonance Imaging
  • Male
  • Motor Skills Disorders / diagnosis
  • Motor Skills Disorders / etiology*
  • Neuropsychological Tests
  • Severity of Illness Index