Efficacy of dietary aloe vera supplementation on hepatic cholesterol and oxidative status in aged rats

J Nutr Sci Vitaminol (Tokyo). 2003 Aug;49(4):292-6. doi: 10.3177/jnsv.49.292.


In the current study, we show the anti-oxidative and hypocholesterol effects of aloe vera in the liver. Male specific pathogen-free (SPF) Fischer 344 rats were randomly assigned to one of four groups: Group A (control) was fed test chow without aloe supplementation; Group B was fed a diet containing a 1% (per weight basis) freeze-dried aloe filet; Group C was fed a diet containing a 1% (per weight basis) charcoal-processed, freeze-dried aloe filet; and Group D was fed a diet containing a charcoal-processed freeze-dried, whole leaf aloe (0.02% per weight basis) in the drinking water. Our results show that a life-long intake of aloe had superior anti-oxidative action against lipid peroxidation in vivo, as indicated by reduced levels of hepatic phosphatidylcholine hydroperoxide. Additional anti-oxidative action was evidenced by enhanced superoxide dismutase (SOD) and catalase activity in groups B and C. Furthermore, our study revealed that hepatic cholesterol significantly increased in the control group during aging in contrast to the aloe-supplemented groups, which showed approximately 30% lower cholesterol levels, thereby an effective hypocholesteremic efficacy. In this report, we suggest that life-long dietary aloe supplementation suppresses free radical-induced oxidative damage and age-related increases in hepatic cholesterol.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging / blood
  • Aging / metabolism*
  • Aloe* / chemistry
  • Animals
  • Anticholesteremic Agents / pharmacology*
  • Catalase / metabolism
  • Cholesterol / blood
  • Cholesterol / metabolism*
  • Chromatography, High Pressure Liquid / methods
  • Dietary Supplements
  • Lipid Peroxidation / drug effects*
  • Liver / metabolism*
  • Male
  • Phosphatidylcholines / analysis
  • Plant Extracts / pharmacology
  • Random Allocation
  • Rats
  • Rats, Inbred F344
  • Specific Pathogen-Free Organisms
  • Superoxide Dismutase / metabolism
  • Treatment Outcome


  • Anticholesteremic Agents
  • Phosphatidylcholines
  • Plant Extracts
  • phosphatidylcholine hydroperoxide
  • Cholesterol
  • Catalase
  • Superoxide Dismutase