Carnosic acid, a component of rosemary (Rosmarinus officinalis L.), promotes synthesis of nerve growth factor in T98G human glioblastoma cells

Biol Pharm Bull. 2003 Nov;26(11):1620-2. doi: 10.1248/bpb.26.1620.


Nerve growth factor (NGF) is a factor vital for the growth and functional maintenance of nerve tissue. The authors found that a rosemary (Rosmarinus officinalis L.) extract enhanced the production of NGF in T98G human glioblastoma cells. Furthermore, the results indicated that carnosic acid and carnosol, which are major components of the rosemary extract, were able to promote markedly enhanced synthesis of NGF.

MeSH terms

  • Abietanes
  • Cell Line, Tumor
  • Diterpenes / chemistry
  • Diterpenes / isolation & purification
  • Diterpenes / pharmacology*
  • Dose-Response Relationship, Drug
  • Glioblastoma / metabolism*
  • Humans
  • Nerve Growth Factor / biosynthesis*
  • Plant Extracts / chemistry
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology*
  • Plant Leaves
  • Rosmarinus*


  • Abietanes
  • Diterpenes
  • Plant Extracts
  • Nerve Growth Factor
  • salvin