Where are the prostate cancer genes?--A summary of eight genome wide searches

Prostate. 2003 Dec 1;57(4):261-9. doi: 10.1002/pros.10300.


Background: There is strong evidence for genetic susceptibility to prostate cancer, but most of the genes underlying this susceptibility remain to be identified.

Methods: We reviewed the results of eight genome-wide linkage searches based on 1,293 families with multiple cases of prostate cancer.

Results: Across these studies, 11 linkage peaks with LOD scores in excess of 2 were identified. However, no chromosomal region was reported as significant at this level by more than one study and only one corresponded to a peak previously suggested by another group.

Conclusions: These results indicate that prostate cancer is genetically complex, and that combined analyses of large family sets will be required to evaluate reliably the linkage evidence.

MeSH terms

  • Genetic Linkage / genetics
  • Genetic Markers
  • Genetic Predisposition to Disease
  • Genome, Human*
  • Humans
  • Lod Score
  • Male
  • Prostatic Neoplasms / genetics*


  • Genetic Markers