Genome-wide scan for linkage in finnish hereditary prostate cancer (HPC) families identifies novel susceptibility loci at 11q14 and 3p25-26

Prostate. 2003 Dec 1;57(4):280-9. doi: 10.1002/pros.10302.


Background: In order to identify predisposition loci to hereditary prostate cancer (HPC), we performed a genome-wide linkage analysis using samples from a genetically homogeneous population, with 13 Finnish multiplex prostate cancer families.

Methods: Altogether 87 DNA samples were genotyped from 13 families. Logarithm-of-odds (LOD) scores were calculated for all autosomes using FASTLINK and GENEHUNTER designating all unaffected men and all women as unknown.

Results: The highest LOD scores in the affected-only analyses were found at 11q14, where the two-point LOD score was 2.97 (theta = 0.0 at D11S901), GENEHUNTER heterogeneity LOD (HLOD) of 3.36, and a non-parametric-linkage (NPL) score of 2.67 (P = 0.008). A second positive site was at 3p25-26, with a two-point LOD score of 2.57 (theta = 0.01 at D3S1297), HLOD of 2.15, and NPL score of 2.27 (P = 0.02).

Conclusions: The results suggest two HPC regions in the Finnish population, which have not been reported previously and warrant further study.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Chromosomes, Human, Pair 11 / genetics
  • Chromosomes, Human, Pair 3 / genetics
  • DNA, Neoplasm / chemistry
  • DNA, Neoplasm / genetics
  • Family
  • Female
  • Finland
  • Genetic Linkage / genetics*
  • Genetic Predisposition to Disease
  • Genome, Human*
  • Humans
  • Male
  • Microsatellite Repeats / genetics
  • Middle Aged
  • Polymerase Chain Reaction
  • Prostatic Neoplasms / genetics*
  • Sequence Analysis, DNA
  • Statistics, Nonparametric
  • Stomach Neoplasms / genetics


  • DNA, Neoplasm