The IGF-1 receptor in cancer biology

Int J Cancer. 2003 Dec 20;107(6):873-7. doi: 10.1002/ijc.11487.


The type 1 insulin-like growth factor receptor (IGF-1R) plays an important role in the establishment and maintenance of the transformed phenotype. It also has a strong antiapoptotic activity and has a significant influence on the control of cell and body size. Downregulation of the IGF-1R leads to massive apoptosis of cancer cells. These characteristics make it an attractive target for anticancer therapy.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Apoptosis
  • Cell Division
  • Cell Transformation, Neoplastic
  • Humans
  • Insulin Receptor Substrate Proteins
  • Insulin-Like Growth Factor I / physiology
  • Insulin-Like Growth Factor II / physiology
  • Mice
  • Neoplasms / pathology
  • Neoplasms / physiopathology*
  • Phosphoproteins / physiology
  • Receptor, IGF Type 1 / physiology*


  • IRS1 protein, human
  • Insulin Receptor Substrate Proteins
  • Irs1 protein, mouse
  • Phosphoproteins
  • Insulin-Like Growth Factor I
  • Insulin-Like Growth Factor II
  • Receptor, IGF Type 1