In a dental practice, 2328 ceramic inlays were placed in 794 patients. The restorations were manufactured chairside using Cerec technology and adhesively inserted at the same appointment. The clinical performance of the restorations was evaluated with the Kaplan-Meier analysis. The probability of survival was 95.5% after 9 years; 35 Cerec restorations were judged as failures. The prognosis for success was not significantly influenced by restoration size, tooth vitality, treatment of caries profunda (CP), type of tooth treated, or whether the restoration was located in the maxilla or mandible. The most common type of failure was the extraction of a tooth. In a clinical follow-up light-microscopic examination of 44 randomly selected restorations, an average composite joint width of 236.3 microns was found. 45.1% of the restorations exhibited a perfect margin, and 47.4% of the investigated joint sections showed underfilled margins.