Comorbidity of schizophrenia and substance abuse: implications for treatment

J Consult Clin Psychol. 1992 Dec;60(6):845-56. doi: 10.1037//0022-006x.60.6.845.


The problem of substance abuse disorders in schizophrenia patients is reviewed, including the prevalence of co-morbid disorders, assessment, hypothesized mechanisms underlying abuse, and the clinical effects of abuse on the course of illness and cognitive functioning. The principles of treatment for dual-diagnosis schizophrenia patients are outlined, and the limitations of existing interventions are noted. Gaps in current knowledge about the impact of substance abuse on schizophrenia and its treatment are identified, and suggestions are made regarding promising avenues of research in this area.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Alcoholism / epidemiology
  • Alcoholism / psychology
  • Alcoholism / rehabilitation*
  • Combined Modality Therapy
  • Comorbidity
  • Humans
  • Schizophrenia / rehabilitation*
  • Schizophrenic Psychology*
  • Substance-Related Disorders / epidemiology
  • Substance-Related Disorders / psychology
  • Substance-Related Disorders / rehabilitation*