Do macrophage innate immune receptors enhance atherogenesis?

Dev Cell. 2003 Nov;5(5):666-8. doi: 10.1016/s1534-5807(03)00329-0.

Abstract

Macrophages play a central role in both innate immunity to infection and atherosclerosis. Castrillo and colleagues report that selected microbial agonists for Toll-like receptors strongly inhibit LXR-mediated cholesterol efflux from macrophages. TLR-LXR crosstalk could explain how nonspecific microbial infections promote atherogenesis.

MeSH terms

  • Animals
  • Arteriosclerosis / immunology
  • Cholesterol / metabolism
  • DNA-Binding Proteins
  • Humans
  • Immunity, Innate*
  • Infections / immunology
  • Infections / physiopathology*
  • Liver X Receptors
  • Macrophages / immunology*
  • Macrophages / metabolism
  • Membrane Glycoproteins / agonists
  • Membrane Glycoproteins / metabolism*
  • Orphan Nuclear Receptors
  • Receptors, Cell Surface / agonists
  • Receptors, Cell Surface / metabolism*
  • Receptors, Cytoplasmic and Nuclear / agonists
  • Receptors, Cytoplasmic and Nuclear / metabolism*
  • Toll-Like Receptors

Substances

  • DNA-Binding Proteins
  • Liver X Receptors
  • Membrane Glycoproteins
  • Orphan Nuclear Receptors
  • Receptors, Cell Surface
  • Receptors, Cytoplasmic and Nuclear
  • Toll-Like Receptors
  • Cholesterol