Thicker than blood: conserved mechanisms in Drosophila and vertebrate hematopoiesis

Dev Cell. 2003 Nov;5(5):673-90. doi: 10.1016/s1534-5807(03)00335-6.

Abstract

Blood development in Drosophila melanogaster shares several interesting features with hematopoiesis in vertebrates, including spatiotemporal regulation as well as the use of similar transcriptional regulators and signaling pathways. In this review, we describe what is known about hematopoietic development in Drosophila and the various cell types generated and their functions. Additionally, the molecular genetic mechanisms of hematopoietic cell fate determination and commitment within Drosophila blood cell lineages are discussed and compared to vertebrate mechanisms.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Lineage
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism
  • Drosophila Proteins / genetics
  • Drosophila Proteins / metabolism
  • Drosophila melanogaster / anatomy & histology
  • Drosophila melanogaster / embryology
  • Drosophila melanogaster / growth & development
  • Drosophila melanogaster / physiology*
  • Hematopoiesis / physiology*
  • Hemocytes / cytology
  • Hemocytes / physiology
  • Lymph Nodes / cytology
  • Lymph Nodes / metabolism
  • Mesoderm / cytology
  • Mesoderm / physiology
  • Signal Transduction / physiology
  • Transcription Factors / genetics
  • Transcription Factors / metabolism

Substances

  • DNA-Binding Proteins
  • Drosophila Proteins
  • Transcription Factors