Validation of a disease-specific measure of health-related quality of life for children with cystic fibrosis

J Pediatr Psychol. 2003 Dec;28(8):535-45. doi: 10.1093/jpepsy/jsg044.


Objective: The purpose of the current study was to evaluate the psychometric properties of the Cystic Fibrosis Questionnaire (CFQ)-Child version, a disease-specific health-related quality of life (HRQOL) measure for children with cystic fibrosis (CF).

Method: The CFQ was administered to 84 children with CF, ranging in age from 7 to 13 years, and their parents.

Results: Multitrait analyses indicated that a majority of items on the CFQ-Child correlated more highly with their hypothesized scale than a competing scale. Internal consistency coefficients were acceptable for all scales (Cronbach's alpha =.60-.76), with the exception of treatment burden (Cronbach's alpha =.44). Results also suggested strong convergence between child and parent-proxy reports on several scales of the CFQ.

Conclusion: Results demonstrated that the CFQ-Child is a reliable and valid measure of HRQOL for children with CF.

Publication types

  • Research Support, Non-U.S. Gov't
  • Validation Study

MeSH terms

  • Adolescent
  • Child
  • Cystic Fibrosis / diagnosis
  • Cystic Fibrosis / psychology*
  • Depressive Disorder / diagnosis
  • Depressive Disorder / epidemiology
  • Depressive Disorder / etiology*
  • Female
  • Humans
  • Male
  • Predictive Value of Tests
  • Psychometrics / methods
  • Quality of Life*
  • Reproducibility of Results
  • Surveys and Questionnaires*
  • Sweat / chemistry