Genistein appears to prevent early postmenopausal bone loss as effectively as hormone replacement therapy

Nutr Rev. 2003 Oct;61(10):346-51. doi: 10.1301/nr.2003.oct.346-351.


Recent data from a randomized, double-blind, placebo-controlled, yearlong clinical trial suggest that supplementation with the dietary phytoestrogen genistein (54 mg/day) may be as effective as hormone replacement therapy in attenuating menopause-related bone loss without causing the associated side effects. These findings may have implications for the development of diet-based strategies aimed at osteoporosis prevention.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Anticarcinogenic Agents / therapeutic use*
  • Bone Density / drug effects
  • Female
  • Genistein / therapeutic use*
  • Hormone Replacement Therapy*
  • Humans
  • Middle Aged
  • Osteoporosis, Postmenopausal / prevention & control*
  • Time Factors


  • Anticarcinogenic Agents
  • Genistein