A short and efficient synthesis of crocetin-dimethylester and crocetindial

J Org Chem. 2003 Nov 14;68(23):9126-8. doi: 10.1021/jo034545y.


In this paper we describe an efficient six-step synthesis of crocetin-dimethylester that could be further reduced to a "four-step" synthesis through the use of in situ procedures. The simplicity of the whole process, the ready availability of starting materials, and the high overall yield render this strategy a very attractive synthesis of this very important compound, which is the key intermediate for the synthesis of several carotenoids and other polyene natural products.