Abstract
Eight antioxidants from five different polyphenolic classes (cinnamic acids, benzoic acids, flavonoids, proanthocyanidins and stilbenes), and the water-soluble vitamin E derivative trolox were examined for their antioxidant activity in-vitro. In addition, the compounds were tested for their cytotoxicity on growing fibroblasts and their inhibition of the classical pathway of the complement system. Procyanidin C1 was shown to be a good scavenger of both DPPH(*) and HO(*), and a strong inhibitor of lipid peroxidation and the classical pathway of the complement system. Consequently, procyanidin C1 was classified as the most promising antioxidant in-vitro of all compounds tested. In contrast, genistein exhibited a very low antioxidant activity in both the lipid peroxidation and the DPPH(*) scavenging assay, a high cytotoxicity and a low complement-inhibiting activity.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Antioxidants / chemistry
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Antioxidants / pharmacology*
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Benzoates / pharmacology
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Biflavonoids / chemistry
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Biflavonoids / pharmacology
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Biphenyl Compounds / chemistry
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Catechin / chemistry
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Catechin / pharmacology
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Cell Survival / drug effects
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Cells, Cultured
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Chromans / chemistry
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Chromans / pharmacology
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Cinnamates / pharmacology
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Dose-Response Relationship, Drug
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Fibroblasts / cytology
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Fibroblasts / drug effects
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Fibroblasts / metabolism
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Flavonoids / chemistry
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Flavonoids / pharmacology*
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Free Radicals / metabolism
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Genistein / chemistry
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Genistein / pharmacology
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Humans
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Hydrazines / chemistry
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Hydroxyl Radical / metabolism
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Lipid Peroxidation / drug effects
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Phenols / chemistry
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Phenols / pharmacology*
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Picrates
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Polyphenols
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Proanthocyanidins / chemistry
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Proanthocyanidins / pharmacology
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Skin / cytology
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Stilbenes / pharmacology
Substances
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Antioxidants
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Benzoates
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Biflavonoids
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Biphenyl Compounds
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Chromans
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Cinnamates
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Flavonoids
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Free Radicals
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Hydrazines
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Phenols
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Picrates
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Polyphenols
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Proanthocyanidins
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Stilbenes
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cinnamic acid
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Hydroxyl Radical
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procyanidin
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Catechin
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1,1-diphenyl-2-picrylhydrazyl
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Genistein
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6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid