Detection of serum anti-Helicobacter pylori immunoglobulin G in patients with different digestive malignant tumors

World J Gastroenterol. 2003 Nov;9(11):2501-4. doi: 10.3748/wjg.v9.i11.2501.

Abstract

Aim: To investigate the seroprevalence of Helicobacter pylori infection in patients with different digestive malignant tumors.

Methods: Enzyme linked immunosorbent assay (ELISA) was used to detect serum anti-Helicobacter pylori IgG antibody in 374 patients with different digestive malignant tumors and 310 healthy subjects (normal control group).

Results: The seroprevalence of Helicobacter pylori infection was 61.50% (230/374) and 46.77% (145/310), respectively, in patients with digestive tumors and normal controls (P<0.05). The seroprevalence was 52.38% (33/63), 86.60% (84/97), 83.14% (84/101), 45.24 (19/42), 51.13% (18/35) and 44.44% (16/36), respectively in patients with carcinomas of esophagus, stomach, duodenum, rectum, colon and liver (P<0.01). In patients with intestinal and diffuse type gastric cancers, the seroprevalence was 93.75% (60/64) and 72.73% (24/33), respectively (P<0.05). In patients with gastric antral and cardiac cancers, the seroprevalence was 96.43% (54/56) and 73.17% (30/41), respectively (P<0.05). In patients with ulcerous and proliferous type duodenal cancers, the seroprevalence of H pylori infection was 91.04% (61/67) and 52.27% (23/44), respectively (P<0.05). In patients with duodenal bulb and descending cancers, the seroprevalence was 94.20% (65/69) and 45.20% (19/42), respectively (P<0.05).

Conclusion: H pylori infection is associated with occurrence and development of gastric and duodenal carcinomas. Furthermore, it is also associated with histological type and locations of gastric and duodenal carcinomas.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Antibodies, Bacterial / blood
  • Duodenal Neoplasms / epidemiology*
  • Duodenal Neoplasms / microbiology
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Helicobacter Infections / epidemiology*
  • Helicobacter pylori / immunology*
  • Humans
  • Immunoglobulin G / blood
  • Male
  • Middle Aged
  • Seroepidemiologic Studies
  • Stomach Neoplasms / epidemiology*
  • Stomach Neoplasms / microbiology

Substances

  • Antibodies, Bacterial
  • Immunoglobulin G