Objective: To report the occurrence and management of pulmonary compromise, marked leukocytosis, and eosinophilia in a patient receiving P-in-oil after IVF and embryo transfer.
Design: Case report.A tertiary referral reproductive medicine unit.
Patient(s): A 29-year-old patient receiving P-in-oil supplementation after IVF embryo transfer.
Intervention(s): Extensive diagnostic testing and surveillance for hypersensitivity to P in sesame oil; development of an alternative oil-based P-in-oil suspension.
Main outcome measure(s): Tolerance of alternative P vehicle; clinical pregnancy.
Result(s): The patient tolerated an alternative P oil vehicle and successfully achieved a clinical pregnancy after frozen embryo transfer.
Conclusion(s): Although rare, hypersensitivity reactions may occur in patients receiving P-in-oil supplementation after IVF embryo transfer. Testing for tolerance and subsequent use of alternative P vehicles may be an effective strategy in managing patients with sensitivity to P-in-oil.