Microbial metabolism of the environmental estrogen bisphenol A

Arch Pharm Res. 2003 Oct;26(10):805-8. doi: 10.1007/BF02980024.

Abstract

Preliminary microbial metabolism studies of bisphenol A (BPA) (1) on twenty six microorganisms have shown that Aspergillus fumigatus is capable of metabolizing BPA. Scale-up fermentation of 1 with A. fumigatus gave a metabolite (2) and its structure was established as bisphenol A-O-beta-D-glucopyranoside (BPAG) based on spectroscopic analyses.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Aspergillus fumigatus / drug effects
  • Aspergillus fumigatus / metabolism*
  • Benzhydryl Compounds
  • Cell Culture Techniques
  • Environmental Pollutants / adverse effects
  • Environmental Pollutants / metabolism*
  • Estrogens / chemistry
  • Estrogens / metabolism
  • Estrogens / pharmacology
  • Glucosides / biosynthesis
  • Glucosides / chemistry
  • Phenols / chemistry
  • Phenols / metabolism*
  • Phenols / pharmacology

Substances

  • 4,4'-isopropylidenediphenol-O-glucopyranoside
  • Benzhydryl Compounds
  • Environmental Pollutants
  • Estrogens
  • Glucosides
  • Phenols
  • bisphenol A