Antioxidant and Memory Enhancing Effects of Purple Sweet Potato Anthocyanin and Cordyceps Mushroom Extract

Arch Pharm Res. 2003 Oct;26(10):821-5. doi: 10.1007/BF02980027.

Abstract

The effects of purple sweet potato anthocyanin (SPA) and Cordyceps mushroom extract (CME) on lipid peroxidation, 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals and cognitive deficits were examined. Both SPA and CME exhibited DPPH radical scavenging activities with similar potency. In contrast, only SPA was shown to effectively inhibit lipid peroxidation initiated by Fe2+ and ascorbic acid in rat brain homogenates. Furthermore, SPA markedly enhanced cognitive performance, assessed by passive avoidance test in ethanol-treated mice. Combined treatments with SPA and CME did not significantly influence the effects of SPA alone. These results demonstrate that anthocyanin prepared from purple sweet potato exhibits memory enhancing effects, which may be associated with its antioxidant properties.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Agaricales / chemistry*
  • Animals
  • Anthocyanins / analysis
  • Anthocyanins / pharmacology*
  • Antioxidants / chemistry
  • Antioxidants / pharmacology*
  • Avoidance Learning / drug effects
  • Avoidance Learning / physiology
  • Biphenyl Compounds
  • Brain / cytology
  • Brain / drug effects
  • Brain / metabolism
  • Cognition Disorders / drug therapy
  • Cognition Disorders / etiology
  • Complex Mixtures / chemistry
  • Cordyceps / isolation & purification
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Drug Therapy, Combination
  • Ethanol / administration & dosage
  • Ethanol / adverse effects
  • Ethanol / antagonists & inhibitors
  • Free Radical Scavengers / pharmacology
  • Hydroxyl Radical / chemistry
  • Hydroxyl Radical / metabolism
  • Ipomoea batatas / chemistry*
  • Lipid Peroxidation / drug effects
  • Lipid Peroxidation / physiology
  • Male
  • Memory Disorders / prevention & control*
  • Mice
  • Mice, Inbred ICR
  • Phytotherapy*
  • Picrates / antagonists & inhibitors
  • Picrates / metabolism
  • Picrates / pharmacology
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology*
  • Rats
  • Rats, Sprague-Dawley

Substances

  • Anthocyanins
  • Antioxidants
  • Biphenyl Compounds
  • Complex Mixtures
  • Free Radical Scavengers
  • Picrates
  • Plant Extracts
  • Hydroxyl Radical
  • Ethanol
  • 1,1-diphenyl-2-picrylhydrazyl