The effect of sol-gel-formed calcium phosphate coatings on bone ingrowth and osteoconductivity of porous-surfaced Ti alloy implants

Biomaterials. 2004 Feb;25(5):865-76. doi: 10.1016/s0142-9612(03)00607-0.


Ti-6Al-4V implants formed with a sintered porous surface for implant fixation by bone ingrowth were prepared with or without the addition of a thin surface layer of calcium phosphate (Ca-P) formed using a sol-gel coating technique over the porous surface. The implants were placed transversely across the tibiae of 17 rabbits. Implanted sites were allowed to heal for 2 weeks, after which specimens were retrieved for morphometric assessment using backscattered scanning electron microscopy and quantitative image analysis. Bone formation along the porous-structured implant surface, was measured in relation to the medial and lateral cortices as an indication of implant surface osteoconductivity. The Absolute Contact Length measurements of endosteal bone growth along the porous-surfaced zone were greater with the Ca-P-coated implants compared to the non-Ca-P-coated implants. The Ca-P-coated implants also displayed a trend towards a significant increase in the area of bone ingrowth (Bone Ingrowth Fraction). Finally, there was significantly greater bone-to-implant contact within the sinter neck regions of the Ca-P-coated implants.

Publication types

  • Comparative Study
  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alloys
  • Animals
  • Bone Substitutes / chemistry*
  • Calcium Phosphates / chemistry*
  • Coated Materials, Biocompatible
  • Crystallization / methods*
  • Freeze Fracturing
  • Image Interpretation, Computer-Assisted / methods
  • Male
  • Materials Testing / methods
  • Microscopy, Electron, Scanning
  • Osseointegration / physiology*
  • Osteogenesis / physiology
  • Phase Transition
  • Porosity
  • Prostheses and Implants*
  • Rabbits
  • Surface Properties
  • Tibia / physiology
  • Tibia / surgery*
  • Tibia / ultrastructure*
  • Titanium / chemistry*


  • Alloys
  • Bone Substitutes
  • Calcium Phosphates
  • Coated Materials, Biocompatible
  • titanium alloy (TiAl6V4)
  • calcium phosphate
  • Titanium