Metadoxine in the treatment of acute and chronic alcoholism: a review

Int J Immunopathol Pharmacol. 2003 Sep-Dec;16(3):207-14. doi: 10.1177/039463200301600304.


Alcohol abuse and alcoholism are responsible for a wide variety of medical problems. The pharmaco-therapeutic aspect of alcoholism includes the use of drugs, with different actions and objectives. Among them, metadoxine seems to be of interest. Metadoxine is able to accelerate the elimination of alcohol from the blood and tissues, to help restore the functional structure of the liver and to relieve neuro-psychological disorders associated with alcohol intoxication. Metadoxine also seems to be safe; in more than 15 years of post-marketing surveillance only minor aspecific and reversible events were monitored in patients exposed to the treatment. In this review the preclinical and clinical results obtained using metadoxine in acute and chronic alcohol intoxication are reported.

Publication types

  • Review

MeSH terms

  • Acute Disease
  • Alcohol Deterrents / chemistry
  • Alcohol Deterrents / pharmacokinetics
  • Alcohol Deterrents / therapeutic use*
  • Alcoholism / drug therapy*
  • Alcoholism / metabolism
  • Animals
  • Drug Combinations
  • Humans
  • Pyridoxine / chemistry
  • Pyridoxine / pharmacokinetics
  • Pyridoxine / therapeutic use*
  • Pyrrolidonecarboxylic Acid / chemistry
  • Pyrrolidonecarboxylic Acid / pharmacokinetics
  • Pyrrolidonecarboxylic Acid / therapeutic use*


  • Alcohol Deterrents
  • Drug Combinations
  • metadoxine
  • Pyridoxine
  • Pyrrolidonecarboxylic Acid