The relationship between T-lymphocyte infiltration, stage, tumour grade and survival in patients undergoing curative surgery for renal cell cancer

E J Bromwich; P A McArdle; K Canna; D C McMillan; A-M McNicol; M Brown; M Aitchison

doi:10.1038/sj.bjc.6601400

The relationship between T-lymphocyte infiltration, stage, tumour grade and survival in patients undergoing curative surgery for renal cell cancer

Br J Cancer. 2003 Nov 17;89(10):1906-8. doi: 10.1038/sj.bjc.6601400.

Authors

E J Bromwich¹, P A McArdle, K Canna, D C McMillan, A-M McNicol, M Brown, M Aitchison

Affiliation

¹ Department of Urology, Gartnavel General Hospital, Glasgow G12 0YN, UK. d.c.mcmillan@clinmed.gla.ac.uk

Abstract

The present study examined the relationship between tumour stage, grade, T-lymphocyte subset infiltration and survival in patients who had undergone potentially curative surgery for renal clear-cell cancer (n=73). Intratumoural CD4+ T-lymphocyte infiltrate was associated with poor cancer-specific survival, independent of grade, in this cohort.

MeSH terms

Aged
Carcinoma, Renal Cell / immunology*
Carcinoma, Renal Cell / pathology*
Carcinoma, Renal Cell / surgery
Cohort Studies
Female
Humans
Immunohistochemistry
Kidney Neoplasms / immunology*
Kidney Neoplasms / pathology*
Kidney Neoplasms / surgery
Male
Middle Aged
Neoplasm Staging*
Survival Analysis
T-Lymphocytes / immunology*
Treatment Outcome