[The PATCHED/Sonic Hedgehog signalling pathway in superficial bladder cancer]

Med Sci (Paris). 2003 Oct;19(10):920-5. doi: 10.1051/medsci/20031910920.
[Article in French]

Abstract

Superficial bladder cancer shows a high frequency of total or partial chromosome 9 losses. Loss of heterozygosity at position 9q22.3 is one of the most frequent and is associated with highly recurrent tumours. The PATCHED gene, ortholog of a gene first described in the drosophila as a segment polarity gene, is located at 9q22.3. It is a member of a signal transduction pathway and a tumour suppressor gene (TSG), involved in basal cell carcinoma. We propose PATCHED as a TSG candidate in superficial bladder cancer.

Publication types

  • Review

MeSH terms

  • Carcinoma, Basal Cell / genetics*
  • Carcinoma, Basal Cell / physiopathology*
  • Chromosomes, Human, Pair 9 / genetics*
  • Genes, Tumor Suppressor
  • Humans
  • Loss of Heterozygosity*
  • Membrane Proteins / genetics*
  • Membrane Proteins / pharmacology*
  • Patched Receptors
  • Receptors, Cell Surface
  • Signal Transduction
  • Urinary Bladder Neoplasms / genetics*
  • Urinary Bladder Neoplasms / physiopathology*

Substances

  • Membrane Proteins
  • Patched Receptors
  • Receptors, Cell Surface