Microfluidic devices fabricated in poly(dimethylsiloxane) for biological studies

Electrophoresis. 2003 Nov;24(21):3563-76. doi: 10.1002/elps.200305584.


This review describes microfluidic systems in poly(dimethylsiloxane) (PDMS) for biological studies. Properties of PDMS that make it a suitable platform for miniaturized biological studies, techniques for fabricating PDMS microstructures, and methods for controlling fluid flow in microchannels are discussed. Biological procedures that have been miniaturized into PDMS-based microdevices include immunoassays, separation of proteins and DNA, sorting and manipulation of cells, studies of cells in microchannels exposed to laminar flows of fluids, and large-scale, combinatorial screening. The review emphasizes the advantages of miniaturization for biological analysis, such as efficiency of the device and special insights into cell biology.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Biology / methods
  • Cells / cytology
  • Dimethylpolysiloxanes*
  • Magnetics
  • Microfluidics / methods*
  • Silicones*


  • Dimethylpolysiloxanes
  • Silicones
  • baysilon