Mechanisms of pathogenesis: evasion of killing by polymorphonuclear leukocytes

Microbes Infect. 2003 Nov;5(14):1329-35. doi: 10.1016/j.micinf.2003.09.011.


Few microorganisms evade killing by neutrophils. Summarized here are the mechanisms used by Yersinia, group A streptococci, Helicobacter, Ehrlichia and Francisella to block phagocytosis, disrupt phagosome maturation or perturb the respiratory burst. Also discussed are mechanisms used by neutrophils to control organisms that replicate inside macrophages.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Bacteria / metabolism
  • Bacteria / pathogenicity*
  • Humans
  • Neutrophils / immunology*
  • Neutrophils / physiology
  • Phagocytosis*
  • Phagosomes / microbiology
  • Phagosomes / physiology