Genome stability: a new member of the RFC family

Curr Biol. 2003 Nov 11;13(22):R873-5. doi: 10.1016/j.cub.2003.10.048.


Three distinct forms of replication factor C are known to play vital roles in genome replication and integrity in eukaryotic cells. A fourth such complex has recently been identified; initial results suggest that this new family member plays an important role during S phase.

Publication types

  • Review

MeSH terms

  • DNA / metabolism
  • DNA Replication / genetics
  • DNA-Binding Proteins / genetics*
  • DNA-Binding Proteins / metabolism*
  • Genomic Instability / genetics*
  • Proliferating Cell Nuclear Antigen / metabolism
  • Replication Protein C
  • S Phase / genetics


  • DNA-Binding Proteins
  • Proliferating Cell Nuclear Antigen
  • DNA
  • Replication Protein C