Psychosocial and reproductive outcomes of gestational trophoblastic diseases

Best Pract Res Clin Obstet Gynaecol. 2003 Dec;17(6):959-68. doi: 10.1016/s1521-6934(03)00093-2.


Current therapy for molar pregnancy and gestational trophoblastic neoplasias (GTNs) has resulted in high cure rates with preservation of fertility, even in the setting of chemotherapy for widespread metastatic disease. Data from the New England Trophoblastic Disease Center on later pregnancies following complete and partial mole, as well as persistent GTN show that patients can, in general, anticipate normal subsequent pregnancy outcome. Nevertheless, patients and their partners often express anxiety and fear related to the risk of disease recurrence and the outcome of subsequent pregnancies after treatment for gestational trophoblastic disease. These psychosocial sequelae may persist for years in both patients and their partners.

Publication types

  • Review

MeSH terms

  • Attitude to Health
  • Chorionic Gonadotropin / blood
  • Emotions
  • Female
  • Gestational Trophoblastic Disease / physiopathology
  • Gestational Trophoblastic Disease / psychology*
  • Humans
  • Hydatidiform Mole / psychology
  • Male
  • Marriage
  • Pregnancy
  • Pregnancy Outcome* / psychology
  • Prognosis
  • Quality of Life
  • Recurrence
  • Stress, Psychological
  • Uterine Neoplasms / psychology


  • Chorionic Gonadotropin