Methamphetamine-induced Neurotoxicity in Mouse Brain Is Attenuated by Ketoprofen, a Non-Steroidal Anti-Inflammatory Drug

Neurosci Lett. 2003 Nov 27;352(1):13-6. doi: 10.1016/j.neulet.2003.08.015.

Abstract

We examined effects of non-steroidal anti-inflammatory drugs (NSAIDs) on methamphetamine (METH)-induced neurotoxicity. Marked reduction of dopamine transporter-positive signals and accumulation of microglial cells in the striatum after METH injections (4 mg/kg x4, i.p. with 2 h-interval) were significantly and dose-dependently attenuated by four injections of ketoprofen (2 or 5 mg/kg x4, s.c.) given 30 min prior to each METH injection, but not by either a low or high dose of aspirin. The present results suggest that the protective effects of ketoprofen against METH-induced neurotoxicity and microgliosis might be based on its inhibitory activity on inflammatory response or on microglia activation, but not on its cyclooxygenase-inhibiting property. This provides a possible new strategy against METH-induced neurotoxicity using commonly used NSAIDs.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
  • Brain / drug effects*
  • Brain / pathology
  • Ketoprofen / pharmacology*
  • Male
  • Methamphetamine / antagonists & inhibitors
  • Methamphetamine / toxicity*
  • Mice
  • Mice, Inbred BALB C
  • Microglia / drug effects
  • Microglia / pathology

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Methamphetamine
  • Ketoprofen