Serotonin modulates auditory information processing in the cochlear nucleus of the rat

Neurosci Lett. 1992 Sep 28;145(1):51-4. doi: 10.1016/0304-3940(92)90201-h.


The effect of iontophoretic application of serotonin (5-HT) was studied in neurons of the cochlear nucleus in the rat. 5-HT inhibited the spontaneous activity in 71%, and the tone-evoked activity in 32% of the neurons. We also observed an excitatory effect, with a longer latency than that of the inhibition, in 40% of the neurons. In some neurons 5-HT had both inhibitory and excitatory effects. Neurons with different response types seem to have different sensitivities to 5-HT. As the effects of 5-HT were generally weaker than those of other putative neurotransmitters, it probably has only a small modulatory influence on auditory processing.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acoustic Stimulation
  • Animals
  • Auditory Pathways / cytology
  • Auditory Pathways / physiology*
  • Cochlea / cytology
  • Cochlea / physiology*
  • Electrodes
  • Female
  • Iontophoresis
  • Rats
  • Rats, Sprague-Dawley
  • Serotonin / physiology*


  • Serotonin