MRI and EEG findings in surgically treated patients with partial seizures due to neuronal migration disorders, their relations to each other and to surgery outcome

Acta Neurol Scand. 2003 Nov;108(5):309-18. doi: 10.1034/j.1600-0404.2003.00153.x.


Objectives: To evaluate magnetic resonance imaging (MRI) and electro-encephalogram (EEG) findings of patients with therapy-resistant partial seizures due to neuronal migration disorders (NMD), and compare them with each other and with surgery outcome.

Material and methods: The MRI, interictal and ictal EEG findings, and their relations to each other in 41 patients with NMD were compared with class IA surgery outcome.

Results: The patients showed an MRI lesion in decreasing frequency from the frontal to the occipital areas. A predominantly extratemporal location of the interictal EEG foci (73.3%) and ictal patterns (82.4%) was therefore apparent, also showing a diminishing frequency from the anterior to the posterior areas. Comparing the EEG foci with the MRI lesions, the same location of the interictal foci was found in 68.4% and of the ictal foci in 52.7%, including several cases with a more widespread EEG focus or MRI lesion. The same location of interictal as well as ictal foci was evident in 85.7%. The most favourable surgery outcome (class IA) was, on average, apparent in patients with an MRI lesion (28.6% vs 25%), a main interictal EEG focus (50% vs 18%) and an ictal seizure pattern (37.5% vs 16.7%) located in the temporal area; likewise, if the interictal focus (30.8% vs 18.2%) and the ictal pattern (31.8% vs 12.5%) showed the same location as the MRI lesion, as well as when the interictal and ictal EEG changes had an equal location (30% vs 20%).

Conclusion: MRI and EEG recordings show relatively close relations to each other and might be important methods to predict surgery outcome in NMD patients.

MeSH terms

  • Adolescent
  • Adult
  • Brain / pathology
  • Brain / physiopathology
  • Cell Movement
  • Child
  • Child, Preschool
  • Electroencephalography
  • Epilepsy, Partial, Motor / pathology*
  • Epilepsy, Partial, Motor / physiopathology*
  • Epilepsy, Partial, Motor / surgery
  • Female
  • Humans
  • Infant
  • Magnetic Resonance Imaging
  • Male
  • Neurons / physiology*
  • Retrospective Studies
  • Treatment Outcome