We report a case of vertebral osteomyelitis due to the coagulase-negative staphylococcus, Staphylococcus lugdunensis. This is only the second such case reported in the literature in an immunocompetent host. When the patient's lumbar spine inflammatory mass was drained, the coagulase-negative staphylococcus obtained was discarded as a likely contaminant. We discuss the situation when coagulase-negative staphylococci require further identification and look at the unique features of S. lugdunensis. Isolation of S. lugdunensis is usually significant, and the organism should not be discarded as a contaminant without careful consideration.