Lacquer crack formation after photodynamic therapy

Eur J Ophthalmol. 2003 Oct;13(8):729-33. doi: 10.1177/112067210301300813.


Purpose: To report the occurrence of a lacquer crack after photodynamic therapy (PDT) of choroidal neovascularization (CNV) in a patient with pathologic myopia.

Methods: PDT was performed with verteporfin, which was activated by a diode laser light at 690 nm.

Results: The left eye of a 42-year-old woman was treated with PDT because of juxtafoveal CNV caused by pathologic myopia. No lacquer crack was present in the macula on either fluorescein or indocyanine green angiography before treatment. The CNV subsided after treatment. However, a large lacquer crack underlying a subretinal hemorrhage was formatted in the macula of the treated eye soon after PDT.

Conclusions: Although the chorioretinal damage produced by PDT is minimal, it is enough to create, directly or indirectly, the basis for the formation of a lacquer crack in an eye with pathologic myopia.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Angiography
  • Choroidal Neovascularization / diagnosis
  • Choroidal Neovascularization / drug therapy*
  • Coloring Agents
  • Female
  • Fluorescein Angiography
  • Fovea Centralis
  • Fundus Oculi
  • Humans
  • Indocyanine Green
  • Photochemotherapy / adverse effects*
  • Photosensitizing Agents / adverse effects*
  • Porphyrins / adverse effects*
  • Retinal Perforations / chemically induced*
  • Retinal Perforations / diagnosis
  • Verteporfin


  • Coloring Agents
  • Photosensitizing Agents
  • Porphyrins
  • Verteporfin
  • Indocyanine Green