Growth factors and bladder cancer: clinical implications of the interactions between growth factors and their urothelial receptors

Semin Surg Oncol. Sep-Oct 1992;8(5):285-92. doi: 10.1002/ssu.2980080507.


Growth factors (GFs) are a class of proteins that bind to specific cell surface receptors (GF-Rs), inducing a variety of responses including mitosis, in susceptible target cells. Abnormal production, expression, and/or function of GFs or GF-Rs can result in unregulated growth, the hallmark of malignant transformation. This chapter reviews those GFs/GF-Rs that have been linked to human bladder cancer. It focuses particularly on one [epidermal growth factor (EGF), which is excreted in urine in high concentrations] and its possible role in the development and growth of urothelial malignancy. Potential clinical applications in diagnosis, staging, prevention, and treatment are discussed.

Publication types

  • Review

MeSH terms

  • Epidermal Growth Factor / physiology
  • Epidermal Growth Factor / urine
  • ErbB Receptors / physiology
  • Growth Substances / chemistry
  • Growth Substances / physiology*
  • Humans
  • Receptors, Somatotropin / physiology*
  • Urinary Bladder Neoplasms / etiology*
  • Urinary Bladder Neoplasms / therapy
  • Urinary Bladder Neoplasms / urine


  • Growth Substances
  • Receptors, Somatotropin
  • Epidermal Growth Factor
  • ErbB Receptors