Functional and structural alterations of the intraparietal sulcus in a developmental dyscalculia of genetic origin

Neuron. 2003 Nov 13;40(4):847-58. doi: 10.1016/s0896-6273(03)00670-6.


Cognitive theories of numerical representation suggest that understanding of numerical quantities is driven by a magnitude representation associated with the intraparietal sulcus and possibly under genetic control. The aim of this study was to investigate, using fMRI and structural imaging, the interaction between the abnormal development of numerical representation in an X-linked condition, Turner syndrome (TS), and the development of the intraparietal sulcus. fMRI during exact and approximate calculation in TS showed an abnormal modulation of intraparietal activations as a function of number size. Morphological analysis revealed an abnormal length, depth, and sulcal geometry of the right intraparietal sulcus, suggesting an important disorganization of this region in TS. Thus, a genetic form of developmental dyscalculia can be related to both functional and structural anomalies of the right intraparietal sulcus, suggesting a crucial role of this region in the development of arithmetic abilities.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Brain Mapping
  • Chromosomes, Human, X / genetics
  • Female
  • Functional Laterality / physiology
  • Genetic Variation / genetics
  • Humans
  • Learning Disabilities / pathology
  • Learning Disabilities / physiopathology*
  • Learning Disabilities / psychology
  • Magnetic Resonance Imaging
  • Male
  • Mathematics
  • Nerve Net / abnormalities
  • Nerve Net / pathology
  • Nerve Net / physiopathology
  • Nervous System Malformations / pathology
  • Nervous System Malformations / physiopathology*
  • Nervous System Malformations / psychology
  • Neural Pathways / abnormalities
  • Neural Pathways / pathology
  • Neural Pathways / physiopathology
  • Neuropsychological Tests
  • Parietal Lobe / abnormalities*
  • Parietal Lobe / pathology
  • Parietal Lobe / physiopathology*
  • Turner Syndrome / complications*
  • Turner Syndrome / physiopathology
  • Turner Syndrome / psychology