Suppressive effects of Active Hexose Correlated Compound on the increased activity of hepatic and renal ornithine decarboxylase induced by oxidative stress

Life Sci. 2003 Dec 19;74(5):593-602. doi: 10.1016/j.lfs.2003.06.038.


Active Hexose Correlated Compound (AHCC), an extract derived from fungi of Basidiomycetes family has been shown to act as a biological response modifier in various disorders. In our present study, ferric nitrilotriacetate (Fe-NTA), which generates hydroxyl radicals in vivo, was given intraperitoneally to rats and AHCC was tested for its ability to suppress oxidative stress and the activity of ornithine decarboxylase (ODC) in the liver and kidney. Substantial increments in glutathione-related enzymes including glutathione reductase, glutathione peroxidase activity as well as oxidized glutathione contents were shown in the liver at 12 h after treatment with Fe-NTA (7.5 mg Fe/kg body weight). Effects of oxidative stress induced by Fe-NTA were also demonstrated by the increase in serum lipid peroxidation, aminotransferases and urinary 8-hydroxy-2'-deoxyguanosine. However, the increases in these parameters were restored to normal in AHCC-pretreated rats. The ODC activity in the liver and kidney was significantly increased by Fe-NTA, while the increased ODC activity induced by Fe-NTA was normalized in AHCC-pretreated rats. These results suggest AHCC acts as a potent antioxidant and protects against disorders induced by oxidative stresses.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 8-Hydroxy-2'-Deoxyguanosine
  • Animals
  • Basidiomycota / chemistry*
  • Biomarkers
  • Blood Urea Nitrogen
  • Carcinogens / toxicity
  • Deoxyguanosine / analogs & derivatives*
  • Deoxyguanosine / urine
  • Enzyme Inhibitors / pharmacology*
  • Ferric Compounds / toxicity
  • Glutathione / metabolism
  • Glutathione Peroxidase / metabolism
  • Glutathione Reductase / metabolism
  • Hexoses / pharmacology
  • Kidney / drug effects
  • Kidney / enzymology*
  • Lipid Peroxidation / drug effects
  • Liver / drug effects
  • Liver / enzymology*
  • Male
  • Nitrilotriacetic Acid / analogs & derivatives*
  • Nitrilotriacetic Acid / toxicity
  • Ornithine Decarboxylase / metabolism
  • Ornithine Decarboxylase Inhibitors*
  • Oxidative Stress / drug effects*
  • Polysaccharides / pharmacology
  • Proteins / metabolism
  • Rats
  • Rats, Wistar
  • Superoxide Dismutase / metabolism


  • Biomarkers
  • Carcinogens
  • Enzyme Inhibitors
  • Ferric Compounds
  • Hexoses
  • Ornithine Decarboxylase Inhibitors
  • Polysaccharides
  • Proteins
  • 8-Hydroxy-2'-Deoxyguanosine
  • Glutathione Peroxidase
  • Superoxide Dismutase
  • Glutathione Reductase
  • Ornithine Decarboxylase
  • Deoxyguanosine
  • Glutathione
  • Nitrilotriacetic Acid
  • Active Hexose Correlated Compound
  • ferric nitrilotriacetate