Endocytic trafficking during Drosophila development

Mech Dev. 2003 Nov;120(11):1265-82. doi: 10.1016/j.mod.2003.06.002.


During the last decade, many of the factors and mechanisms controlling membrane and protein trafficking in general and endocytic trafficking in particular have been uncovered. We have a detailed understanding of the different endocytic trafficking steps: plasma membrane budding, endocytic vesicle motility and fusion with the endosome, recycling, transcytosis and lysosomal degradation. The kinetics and trafficking pathway of many signaling receptors and the relevance of endocytic trafficking during signaling in many mammalian cultured cells are also well understood. However, only in recent years has the role of endocytic trafficking during cell-to-cell communication during development, i.e. during patterning, induction and lateral inhibition, begun to be explored. The contribution of Drosophila developmental genetics and cell biology has been fundamental in elucidating the essential role of endocytosis during these processes. Reviewed here are some of the recent developments on the role of endocytic trafficking during long- and short-range signaling and during lateral inhibition.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Body Patterning
  • Cell Communication
  • Cholesterol / metabolism
  • Diffusion
  • Drosophila Proteins / metabolism
  • Drosophila Proteins / physiology*
  • Drosophila melanogaster / embryology*
  • Endocytosis*
  • Gene Expression Regulation, Developmental*
  • Hedgehog Proteins
  • Membrane Proteins / metabolism
  • Models, Biological
  • Proto-Oncogene Proteins / metabolism
  • Receptors, Notch
  • Signal Transduction
  • Transforming Growth Factor beta / metabolism
  • Wnt1 Protein


  • Drosophila Proteins
  • Hedgehog Proteins
  • Membrane Proteins
  • N protein, Drosophila
  • Proto-Oncogene Proteins
  • Receptors, Notch
  • Transforming Growth Factor beta
  • Wnt1 Protein
  • dpp protein, Drosophila
  • wg protein, Drosophila
  • hh protein, Drosophila
  • Cholesterol