Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 60 (11), 1524-34

Advances in Neuropathic Pain: Diagnosis, Mechanisms, and Treatment Recommendations


Advances in Neuropathic Pain: Diagnosis, Mechanisms, and Treatment Recommendations

Robert H Dworkin et al. Arch Neurol.


Chronic neuropathic pain, caused by lesions in the peripheral or central nervous system, comes in many forms. We describe current approaches to the diagnosis and assessment of neuropathic pain and discuss the results of recent research on its pathophysiologic mechanisms. Randomized controlled clinical trials of gabapentin, the 5% lidocaine patch, opioid analgesics, tramadol hydrochloride, and tricyclic antidepressants provide an evidence-based approach to the treatment of neuropathic pain, and specific recommendations are presented for use of these medications. Continued progress in basic and clinical research on the pathophysiologic mechanisms of neuropathic pain may make it possible to predict effective treatments for individual patients by application of a pain mechanism-based approach.

Comment in

  • Pain 2003
    RN Rosenberg. Arch Neurol 60 (11), 1520. PMID 14623721.

Similar articles

  • Therapeutic Management of Chronic Neuropathic Pain: An Examination of Pharmacologic Treatment
    A Vadalouca et al. Ann N Y Acad Sci 1088, 164-86. PMID 17192564. - Review
    Neuropathic pain is defined as pain caused by a lesion in the nervous system and is common in clinical practice. Diagnosis can be difficult. Recommendations for first-lin …
  • Management of Neuropathic Pain
    TS Jensen et al. Curr Opin Support Palliat Care 1 (2), 126-31. PMID 18685353. - Review
    For each patient, considerations on the underlying pain mechanisms, immediate and potential long-term side effects, and price as well as comorbidities and concurrent medi …
  • Neuropathic Pain: A Clinical Perspective
    R Baron. Handb Exp Pharmacol (194), 3-30. PMID 19655103. - Review
    Neuropathic pain syndromes, i.e., pain after a lesion or disease of the peripheral or central nervous system, are clinically characterized by spontaneous pain (ongoing, p …
  • Chronic Neuropathic Pain: Mechanisms, Drug Targets and Measurement
    NB Finnerup et al. Fundam Clin Pharmacol 21 (2), 129-36. PMID 17391285. - Review
    Neuropathic pain is common in many diseases or injuries of the peripheral or central nervous system, and has a substantial impact on quality of life and mood. Lesions of …
  • Recommendations for Neuropathic Pain Treatment
    V Demarin et al. Acta Clin Croat 47 (3), 181-91. PMID 19175069.
    Damage to the somatosensory nervous system poses a risk for the development of neuropathic pain. Such an injury to the nervous system results in a series of neurobiologic …
See all similar articles

Cited by 209 PubMed Central articles

See all "Cited by" articles

Publication types

LinkOut - more resources